Failure to Thrive (FTT)

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8 أقسام

شرح المدرسين

د. رناد العجارمة

د. رناد العجارمة

تحتاج اشتراك

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Introduction

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Definition

  • Cessation of weight gain after a period of stable growth that manifests as weight below the 3rd percentile for age, Weight for height below the 5th percentile.
  • Failure to thrive is growth that has fallen, crossing 2 major percentile curves in a short time.
  • Any change below the 5th percentile suggests a child is at risk for FTT.
Definition of Failure to Thrive (FTT)
Number of Points on Growth Chart Failure to Thrive Characteristics
1 point
  • Weight below the 3rd percentile for age.
  • Weight for height less than the 5th percentile.
  • Weight 20% or more less than ideal weight for height.
Series of points
  • Weight gain < 20 g/day from 0 to 3 months of age.
  • Weight gain < 15 g/day from 3 to 6 months of age.
  • Downward crossing of 2 major percentile curves.

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Presentation

  • The degree of FTT is best evaluated by measuring weight and height (the weight height ratio) at multiple points over time.
    Typically, FTTis first characterized by a decrease in weight for age while height and HC are preserved.
  • Progressive FTT due to chronic malnutrition can also result in loss of height.
  • In the absence of wasting, abnormal linear growth would not suggest FTT.

 

Note  
In FTT, the first growth parameter that shows a fall off is the weight curve, then the height curve, and finally the head circumference curve. ملاحظة

 

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Risk Factors

  • Organic risk factors: prematurity, congenital malformations, neuromuscular disorders, abnormal suck/swallow coordination, intrauterine infections, exposure to drugs and/or otherntoxins.
  • Nononorganic (psychosocial) risk factors: familial dysfunction, maternal depression, poverty, and low food security
  • Poverty remains the major risk factor for FTT.
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Etiology

  • FTT can be divided into 2 main categories:
    • Inadequate intake (calories not offered by an adult or calories not ingested by the infant)
    • Altered metabolism (calories not retained or used by the infant or increased metabolic need compared to caloric intake)
Causes of FTT
Inadequate intake
  • Improper formula mixing
  • Decreased food intake (cleft palate, CNS disorder)
  • Family dysfunction
  • Maternal depression
  • Psychosocial and behavioral feeding problems
Excessive calorie loss
  • Gastrointestinal disorders (malabsorption due to small or large intestinal disorders, pancreatic disease [inadequate enzyme], infection, anatomic defects [e.g., short-gut syndrome, blind loop syndrome], severe liver disease with impaired bile metabolism)
  • Endocrine disorders (diabetes mellitus)
  • Renal disorders (renal tubular acidosis, renal dysplasia or other structural anomaly, nephrogenic diabetes insipidus, chronic kidney disease)
Excessive calorie consumption
  • Cardiopulmonary disorders (congenital heart disease, cystic fibrosis)
  • Malignancies
  • Hyperthyroidism
  • Chronic or recurrent infections (HIV, primary immunodeficiencies)
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Clinical Picture

  • If severe psychosocial FTT is present→ gaze disturbances—“wary watchfulness” or total avoidance of eye contact, apathetic withdrawal,developmental delays in language and social behavior.
  • Wasting of subcutaneous tissue, especially lateral buttocks, thighs, and upper arms
  • Alopecia.
  • Dermatitis.
  • Kwashiorkor or marasmus.
  • Specific physical findings suggestive of organic etiologies can be noted.

 

Note  
If only weight parameter is affected → Mostly due to inadequatecaorie intake.
If Both weight and height are below the 5th percentile→ suspect endocrinological disorder.
If weight,height, and HC are all affected→ suspect IUGR, genetic disorders.
ملاحظة

 

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Diagnosis

Consider laboratory studies in a stepwise fashion, based on history and physical exam, which may include:

  • Urine analysis and urine culture; urine-reducing substances.
  • CBC with differential.
  • Stool test for reducing substances.
  • Fecal fat.
  • Electrolytes.
  • BUN and creatinine.
  • Serum transaminases.
  • Total protein and albumin.
  • Thyroid function studies.
  • Sweat chloride.
  • Review of newborn screen (Serum amino acids, urine organic acid screen, serum ammonia.
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Treatment

  • Organic FTT: Treat the underlying medical condition, along with nutritional rehabilitation.
  • Non-Organic FTT: Provide nutritional education and psychosocial interventions, involve social services if neglect is suspected.
  • Mixed FTT: Address both medical and psychosocial factors.
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